Challenges facing colloidal delivery systems: From synthesis to the clinic

APR Johnston; GK Such; SL Ng; F Caruso

Journal article

Challenges facing colloidal delivery systems: From synthesis to the clinic

APR Johnston, GK Such, SL Ng, F Caruso

Current Opinion in Colloid and Interface Science | Published : 2011

DOI: 10.1016/j.cocis.2010.11.003

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Abstract

Improving therapeutic delivery to the body will have significant benefits for the treatment of a variety of diseases. Incorporating drugs inside engineered colloidal carriers is a promising approach that can lead to improved drug delivery. Such carriers offer a number of advantages, as they can protect therapeutic cargo from degradation by the body, limit potentially harmful side effects of the drug, and also allow targeted drug delivery to the desired site of action. Colloidal carriers have the potential to enable clinical use of a number of therapeutics, such as siRNA and peptides, which if administered in their naked form can degrade before demonstrating a viable therapeutic effect. A num..

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University of Melbourne Researchers

Georgina Such Author

Frank Caruso Author

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Grants

Awarded by Australian Research Council

Funding Acknowledgements

This work was supported by the Australian Research Council under the Federation Fellowship, Discovery Project and Postdoctoral Fellowship schemes, and by the National Health and Medical Research Council under the Program Grant 487922. We thank Dr Yan Yan, Dr Hannah Lomas and Marc Riemer for the critical reading of the manuscript.